Pakistani intelligence officials say suspected US drones fired four missiles at a house near the Afghan border, killing seven people.
The officials say Thursday's strike occurred in the Ramzak area of the North Waziristan tribal region. They spoke on condition of anonymity because they were not authorized to talk to the media.
North Waziristan is the main sanctuary for Al Qaeda and Taliban militants in Pakistan and has been repeatedly hit by US drone strikes.
The US does not acknowledge the CIA-run drone programme in Pakistan publicly, but officials have said privately that the strikes have killed many senior Taliban and Al Qaeda commanders.