A convoy of more than 100 vehicles loaded with aid bound for the Gaza Strip left London on Saturday.
The convoy, including 12 ambulances and a fire engine, is bearing more than one million pounds ($1.4 million) worth of aid.
The vehicles will travel 8,000 kilometres through France, Spain and North Africa, crossing from Egypt into Gaza at Rafah in early March.
The convoy was organised by the Viva Palestine umbrella group.
Hundreds of volunteers are driving the convoy, which includes a boat and trucks full of medicines, tools, clothes, blankets and shoe-boxes bearing gifts for children.
"There is an intifada sweeping Britain. It is a massive and peaceful movement in support of the beleaguered population of Gaza and Palestine," said pro-Palestinian lawmaker George Galloway, who will help drive the convoy.
"It is happening everywhere, but is especially strong in the north of England and especially among young Muslims.
"We will lead the biggest convoy of British vehicles across North Africa since Montgomery."
Britain's Field Marshal Bernard Montgomery commanded Allied forces at the Battle of El Alamein in Egypt in 1942, a turning point in World War II.