9.40 AM Monday, 22 July 2024
  • City Fajr Shuruq Duhr Asr Magrib Isha
  • Dubai 04:14 05:38 12:28 15:52 19:12 20:36
22 July 2024

Melanotan 2 Peptide: Possible Research Functions

By E247

A synthetic peptide that is proposed to mimic alpha-melanocyte-stimulating hormone is Melanotan 2 (MT-2). Because of its shorter amino acid sequence, MT-2 is thought to have a higher influence on melanocortin receptors 3 and 4, which are implicated in inhibiting hunger  signaling as well as erectile function, compared to Melanotan 1 (afamelanotide).

Research in animal models has suggested that stimulating sexual excitement and acting as a sunless tanning agent are hypothesized to be two MT-2 impacts; the compound is also speculated to potentially inhibit appetite and induce neuroplasticity to mitigate addiction feedback mechanisms.

Melanotan 2 Peptide: What is it?

In summary, Melanotan is a manufactured peptide that may have structural similarities with alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide hormone generated by the pituitary gland.

The peptide α-MSH is believed to exert different impacts. It is thought to attach to the melanocortin receptor family members and regulate many physiological processes.

Take MC-1R, for example; it is one of the melanocortin receptors hypothesized to impact melanin synthesis. Melanocytes are specialized cells found all over the skin that are considered to generate melanin, the pigment that gives skin its darker tone. Raising the melanin content may make the skin barrier more resistant to solar damage.

Research indicates that Melanotan may potentially trigger a cascade of further actions via the melanocortin receptors. As an example, MC-3R, the third melanocortin receptor, may have a role in controlling hunger. For that reason, Melanotan has been suggested as a means of controlling food intake in animal models.

Investigations purport that Melanotan 2 may potentially increase libido and regulate erectile function, likely due to its action on the fourth melanocortin receptor, MC-4R, which is considered to play a role in controlling sexual activity. Melanotan may be described as an adaptable peptide.

Melanotan 1 and Melanotan 2 are the two varieties of the compound, sometimes abbreviated as MT-1 and MT-2. Let's compare and contrast these two peptides and see where they overlap and diverge.

Melanotan 1 vs. Melanotan 2

Both type 1 and type 2 Melanotan exist. They are often known as Melanotan I (MT-1) and Melanotan II (MT-2). 

The main difference between them is their chemical structure. MT-2 is a shorter, more elliptical peptide than MT-1, which is longer and straighter. Due to their structural differences, they have been hypothesized to bind to melanocortin receptors differently and therefore exert different effects.

 Studies have suggested that Melanotan 1 may:

  • Pigment skin and follicle cells without UV exposure;
  • May be relevant for study in the context of erythropoietic protoporphyria.

Melanotan 1's impacts are believed to wear off faster than Melanotan II due to the former's shorter half-life. Melanotan II is more popular among researchers and usually costs less to procure.

 As suggested by previous studies, Melanotan 2 may:

  • Potentially increase skin pigmentation with UV exposure;
  • May potentially influence hunger and libido through melanocortin receptors.

Melanotan 2 is a research chemical that is often less costly than Melanotan I and has a longer half-life. As a result, MT-2 is much more well-researched by scientists than Melanotan I.

Melanotan 2 Peptide Potential

Melanotan has been suggested in previous studies to have the following possible impacts:

  • Studies suggest that the tanning rate may be increased by Melanotan. Additionally, it may potentially lessen the likelihood of skin cancer and protect against UV damage per research in rat models.
  • Research indicates Melanotan may alter food intake patterns and may potentially decrease hunger hormone signalling.
  • Melanocortin receptors are part of the machinery that controls blood sugar levels. Investigations purport that Melanotan may have the potential to promote fat loss. It has been hypothesized that Melanotan 2 may potentially impact animal models of diabetes to control blood sugar levels.
  • Findings imply that reducing impulsive behaviors, particularly addictive behaviors, may be one function of MT-2. For instance, after receiving concentrations of Melanotan, rats with alcohol addiction appeared to have exhibited less ethonal-seeking behavior.
  • Melanotan presentations have been extensively examined for their potential on erectile function and libido, potentially mitigating instances of erectile dysfunction.

Melanotan's potential is reputedly remarkable. Their presence has sparked intense interest in studying chemicals among scientists worldwide.

Buying Melanotan 2 Peptide Online

Scientists considering Melanotan studies may be weighing the properties and risks. We hope our advice has eased their minds and directed them to a reliable source for research-grade Melanotan.

Researchers investigating Melanotan 2 and its potential should refer to the recommendations above when selecting a vendor. Doing so will increase the likelihood of locating pure Melanotan for sale and decrease the likelihood of losing money. Scientists interested in high-quality and affordable peptides are encouraged to visit the Core Peptides website. Please note that none of the compounds mentioned in this paper have been approved for human or animal consumption and should not be ac, acquired or utilized by unlicensed individuals outside of contained research environments such as laboratories.



[i] Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159. doi:10.1007/s00441-019-03016-8


[ii] Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066-19077. Published 2014 Nov 19. doi:10.3390/molecules191119066


[iii] Vukojevic J, Milavić M, Perović D, et al. Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res. 2022;17(3):482-487. doi:10.4103/1673-5374.320969


[iv] Knezevic M, Gojkovic S, Krezic I, et al. Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension. Biomedicines. 2021;9(6):609. Published 2021 May 26. doi:10.3390/biomedicines9060609


[v] Hsieh MJ, Lee CH, Chueh HY, et al. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Sci Rep. 2020;10(1):17078. Published 2020 Oct 13. doi:10.1038/s41598-020-74022-y


[vi] Lozic M, Stambolija V, Krezic I, et al. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emerg Med Int. 2020;2020:6805354. Published 2020 May 27. doi:10.1155/2020/6805354


[vii] Lee E, Padgett B. Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain. Altern Ther Health Med. 2021;27(4):8-13.


[viii] Harty PS, Zabriskie HA, Erickson JL, Molling PE, Kerksick CM, Jagim AR. Multi-ingredient pre-workout supplements, safety implications, and performance outcomes: a brief review. J Int Soc Sports Nutr. 2018;15(1):41. Published 2018 Aug 8. doi:10.1186/s12970-018-0247-6