Manchester United and Chelsea will meet in the FA Cup quarterfinals if they win their fifth-round matches.
Defending champion Chelsea, which is looking to win the competition for a fourth time in five years, advanced with a 4-0 victory over Brentford in a fourth-round replay Sunday.
Chelsea travels to Middlesbrough on Feb. 27 in the fifth round. Premier League leader United plays Reading in that round Monday.
Manchester City, which beat Leeds on Sunday, will host second-tier club Barnsley in the last-eight on March 9 or 10.
Wigan will play the winner of the replay between Everton and Oldham after they drew Saturday.
There is guaranteed to be a second-tier side in the semifinals at Wembley Stadium in April after Millwall was drawn Sunday to face Blackburn in the quarterfinals.
The FA Cup produced goals rather than shocks, with Chelsea, Manchester City and Wigan scoring four times each Sunday to knock out lower-league opponents.
Held to a 2-2 tie by third-tier Brentford three weeks ago, Chelsea got second-half goals from Juan Mata, Oscar, Frank Lampard and John Terry to win its fourth-round replay 4-0. Lampard's goal was his 199th for the Blues, three behind the club record set by Bobby Tambling from 1959-70.
Chelsea will play at Middlesbrough on Feb. 27 to decide who plays the winner of Monday's match between Manchester United and Reading.
Manchester City defeated second-tier Leeds 4-0 and advanced to a quarterfinal against Barnsley. After Yaya Toure scored five minutes in, Sergio Aguero converted a penalty kick, then helped set up Carlos Tevez's second-half goal and scored the finale.
Wigan beat second-tier Huddersfield 4-1 as Arouna Kone scored twice and Callum McManaman and James McArthur had one goal each, and it will play Everton or Oldham. Millwall meets Blackburn, guaranteeing there will be a second-tier club in the semifinals at Wembley Stadium in April.
In the weekend's only Premier League game, Liverpool routed Swansea 5-0. Philippe Coutinho, Jose Enrique and Luis Suarez scored between successful penalty kicks by Steven Gerrard and Daniel Sturridge.
Liverpool (10-8-9) moved into seventh place, two points ahead of the Swans (9-8-10).
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