Ciro Immobile scored a hat-trick as Lazio thrashed ten-man Sampdoria 5-1 on Saturday to consolidate third place in Serie A and keep the pressure on leaders Juventus and Inter Milan.
But Napoli lost 2-0 at home to Fiorentina, leaving last season's runners-up without a league win at their San Paolo Stadium since October 19 ahead of hosting Barcelona in the Champions League in a month's time.
Simone Inzaghi's Lazio extended their club record winning streak to 11 league games as they target a first Serie A title since 2000 with Immobile the division's runaway top scorer with 23 goals.
"If we get to seven, eight, ten games from the end and we are still there, why not try to still believe? But for now the goal remains the Champions League," insisted Immobile.
"The important thing is to continue like this without getting carried away."
Immobile is on course to overtake Gonzalo Higuain's Serie A record of 36 goals scored for Napoli in the 2015-2016 season.
"Only Higuain achieved this so it's tough," added Immobile, whose previous best was 29 goals in the 2017-2018 campaign.
"But with these teammates, this crowd, this enthusiasm, we can continue to do well, and hopefully I can keep scoring."
Sampdoria had beaten Brescia 5-1 last time out but were overrun by the Romans who move three points behind Juventus and one adrift of Inter Milan.
Atalanta and Roma are ten points behind.
Eight-time reigning champions Juventus host Parma on Sunday with Inter at Lecce.
'Play with heart'
Immobile played a role in Felipe Caicedo's opener on just seven minutes at the Stadio Olimpico.
He added two more in a three-minute first-half spell, the first from the spot after a Nicola Murru handball, to put Lazio three goals up after 20 minutes.
Angolan defender Bastos tapped in nine minutes after the break, with Immobile converting a second penalty on 65 minutes.
Sampdoria played the final quarter of an hour a man down after Julian Chabot was sent off for bringing down Bobby Adekanye.
Karol Linetty pulled a goal back for the Genoa side on 69 minutes, but Claudio Ranieri's men are now 16th, five points above the relegation zone.
Ranieri lamented "the worst game" since he took over in October.
"Lazio were magnificent," said the former Roma boss. "They are having fun and play with heart."
- Napoli in freefall -
Napoli fell to their third consecutive defeat and fourth in a row at home against Fiorentina.
Gennaro Gattuso replaced Carlo Ancelotti last month, but the former AC Milan boss has lost four of five games since then.
Federico Chiesa and Dusan Vlahovic scored in either half to give the Tuscany side back-to-back wins for the first time in nearly three months.
Chiesa opened the scoring on 26 minutes with Vlahovic curling in a second with quarter of an hour to go.
The southerners are in 13th position, closer to the relegation zone than the Champions League places. Fiorentina moved up to 12th.
In Reggio Emilia, Sassuolo eased their relegation fears with a come-from-behind 2-1 win over Europa League hopefuls Torino.
The hosts fell behind after Manuel Locatelli turned into his own net on 20 minutes.
But Ivory Coast international Jeremie Boga scored a stunning long-range goal after an hour and then set up Domenico Berardi for the winner on 73 minutes.
Torino, in eighth, can be overtaken by Hellas Verona and AC Milan, who play on Sunday.
Sassuolo are eight points above the drop zone.
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