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Real Madrid and Dortmund go through

Referee Bahattin Duran sends off Nani of Manchester United during the UEFA Champions League Round of 16 second leg match against Real Madrid at Old Trafford on March 5, 2013 in Manchester, United Kingdom. (GETTY)

By Reuters

Real Madrid and Borussia Dortmund became the first teams through to the Champions League quarter-finals with contrasting wins over Manchester United and Shakhtar Donetsk on Tuesday.

Real came from behind to win 2-1 at Old Trafford and advance 3-2 on aggregate after a controversial red card for winger Nani rocked United early in the second half, while Dortmund swept to a 3-0 home win to go through 5-2.

Real, held 1-1 in the first leg at the Bernabeu, trailed to a Sergio Ramos own goal just after the break but scored twice in three minutes soon after Nani was shown a shock straight red after his high foot caught Alvaro Arbeloa in the 56th minute.

Real's Luka Modric came off the bench to curl in a lovely shot in the 66th minute and former United favourite Cristiano Ronaldo slid in the second to silence the crowd and keep Madrid on course for a 10th European Cup.

Dortmund, who topped their qualifying group above Real, were well-placed at 2-2 after the opener in Ukraine and took complete control with first-half goals by Felipe Santana and Mario Goetze before Jakub Blaszczykowski completed the job after an hour.

There are two more last 16 matches on Wednesday with Juventus taking a 3-0 lead into their home game against Celtic while Paris St Germain take on Valencia in France 2-1 up.

The remaining four games are being played next week and the draw for the quarter-finals will take place on March 15.