Abu Dhabi-based Etihad Airways, the national airline of the UAE, said on Thursday that it had suspended flights between Abu Dhabi and Damascus with immediate effect and until further notice.
The decision, while not taken lightly, has been made due to the deteriorating security position in Syria.
The safety of passengers and crew is paramount to the airline, the carrier said in a statement send to Emirates 24l7.
Etihad Airways will notify affected passengers and offer a full refund for unused tickets.
The Etihad website said flights from Abu Dhabi to Beirut in Lebanon neighbouring Syria will continue as normal.
Last month, Royal Jordanian also suspended flights to Damascus and the northern Syrian city of Aleppo following deepening unrest in Jordan's northern neighbour.