Mohammad Amir quit Pakistan's one-day series against the West Indies and flew home on Tuesday after his mother was taken seriously ill, the Pakistan Cricket Board said.
The 24-year-old left for Lahore and will miss the third and final one-day international against West Indies in Abu Dhabi on Wednesday.
"The team management has allowed Amir to return home to attend to his mother who is seriously ill," the PCB said in a statement.
Amir took a total of two wickets in the first two one-day internationals in Sharjah which Pakistan won by 111 and 59 runs respectively.
But he is expected to return for the first of three Tests in Dubai, which will be played under lights with a pink ball, starting from October 13.
Pakistan also have fast bowlers Rahat Ali and Sohail Khan in the squad, one of whom is likely to take Amir's place on Wednesday.
Pakistan whitewashed West Indies 3-0 in the Twenty20 series which preceded the one-day internationals.