Artificially stimulating the brain's feel-good centre boosts immunity in mice in a way that could help explain the power of placebos, a study reported Monday.
"Our findings indicate that activation of areas of the brain associated with positive expectations can affect how the body copes with diseases," said senior author Asya Rolls, an assistant professor at the Technion-Israel Institute of Technology's Faculty of Medicine.
The findings, reported in Nature Medicine, "might one day lead to the development of new drugs that utilise the brain's potential to cure," she said.
It has long been known that the human brain's reward system, which mediates pleasure, can be activated with a dummy pill devoid of any active ingredients - known as a placebo - if the person taking it thinks it's real medicine.
"But it was not clear whether this could impact physical well-being," Rolls told AFP.
Nor did scientists know - if, indeed, an immune response was strengthened - exactly how the signal travelled through the body.
Rolls and colleagues incubated immune cells from mice exposed to deadly E. coli bacteria after specific cells in the animals' reward centre had been stimulated.
These immune cells were at least twice as effective in killing bacteria than ordinary ones, they reported.
In a second test, the scientists vaccinated different mice with the same immune cells.
Thirty days later, the new set of rodents was likewise twice as likely to be able to fight off infection.